The problem about the stability of tunnel surrounding rock is always an important research object of geotechnical engineering, and the right or wrong of the result from stability analysis on surrounding rock is related to success or failure of an underground project.In order to study the deformation rules of weak surrounding rock along with lateral
Intracellular biochemical parameters, such as the expression level of gene products, are considered to be optimized so that a biological system, including the parameters, works effectively.Those parameters should have read more some permissible range so that the systems have robustness against perturbations, such as noise in gene expression.However
Outcome of host-pathogen encounter is determined by the complex interplay between protective bacterial and host defense strategies.This complexity further amplifies with the existence of cell-to-cell phenotypic heterogeneity in pathogens which remains largely unexplored.In this study, we illustrated that heterogeneous expression of pneumolysin (Ply
Friedelin (1), 3b-friedelinol (2), 28-hydroxyfriedelin (3), 16a-hydroxyfriedelin (4), 30-hydroxyfriedelin (5) and 16a,28-dihydroxyfriedelin (6) were isolated through fractionation of the hexane extract obtained from branches of Salacia elliptica.After a week in alarecre.com CDCl3 solution, 16a-hydroxyfriedelin (4) reacted turning into 3-oxo-16-meth